A current evaluation of the safety of angiotensin receptor blockers and direct renin inhibitors

The safety of angiotensin II receptor blockers (ARBs) for the treatment of hypertension and cardiovascular and renal diseases has been well documented in numerous randomized clinical trials involving thousands of patients. However, recent concerns have surfaced about possible links between ARBs and increased risks of myocardial infarction and cancer. Less is known about the safety of the direct renin inhibitor aliskiren, which was approved as an antihypertensive in 2007. This article provides a detailed review of the safety of ARBs and aliskiren, with an emphasis on the risks of cancer and myocardial infarction associated with ARBs. Safety data were identified by searching PubMed and Food and Drug Administration (FDA) Web sites through April 2011. ARBs are generally well tolerated, with no known class-specific adverse events. The possibility of an increased risk of myocardial infarction associated with ARBs was suggested predominantly because the Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) trial reported a statistically significant increase in the incidence of myocardial infarction with valsartan compared with amlodipine. However, no large-scale, randomized clinical trials published after the VALUE study have shown a statistically significant increase in the incidence of myocardial infarction associated with ARBs compared with placebo or non-ARBs. Meta-analyses examining the risk of cancer associated with ARBs have produced conflicting results, most likely due to the inherent limitations of analyzing heterogeneous data and a lack of published cancer data. An ongoing safety investigation by the FDA has not concluded that ARBs increase the risk of cancer. Pooled safety results from clinical trials indicate that aliskiren is well tolerated, with a safety profile similar to that of placebo. ARBs and aliskiren are well tolerated in patients with hypertension and certain cardiovascular and renal conditions; their benefits outweigh possible safety concerns

UPAYA MENINGKATKAN DISIPLIN KEHADIRAN STAF TATA USAHA DALAM MELAKSANAKAN TUGAS MELALUI PENERAPAN INSENTIF PROGRESIF DAN RETROGRESIF DI SMAN 1 SEKOTONG, LOMBOK BARAT, NTB TAHUN AJARAN 2021-2022

This research is due to the writer’s observation on the low presence rate of the administration officers impacting to the School Profile, Service, Performance, Achievement and Participation to the Sekotong Community Secondary School becoming hard to realize. Based on this circumstance, the writer’s as a principal make a policy by giving progressive and retrogressive incentive.  It is designed as a School Action Research. It i(1) is a participatory study stressing Action and Reflection based on the rational and logical consideration to improve a real condition. (2) deepens the understanding on the action carried out; (3) is to improve practical learning condition of a school. Shortly this school action research aims at finding real problems on the school as well as finding its scientific solution. This School Action Research is a qualitative. To carry out this research, an attendance list and questionnaire are used. The first is used daily, and the latter is used at the end of the Cycle as a part of evaluation and reflection. The implementation of the incentive is observed in 2 cycles. The result shows that 7 of the 10 administration officers improve their attendance in carrying their tasks at the level of 70%.   Abstrak Penelitian ini dilatarbelakangi oleh hasil pengamatan penulis terhadap tingkat kehadiran staf tata usaha yang rendah yang berakibat pada arsitektur 5 P (Profile, Pelayanan, Penampilan, Prestasi dan Peran Serta Masyarakat) SMAN 1 Sekotong menjadi sulit terrealisasi. Melihat hal ini penulis selaku kepala sekolah mengambil kebijakan berupa pemberian insentif bersifat progresif dan retrogresif Desain penelitian yang digunakan dalam penelitian ini adalah desain Penelitian Tindakan Sekolah (PTS). Penelitian Tindakan Sekolah merupakan “(1) penelitian partisipatoris yang menekankan pada tindakan dan refleksi berdasarkan pertimbangan rasional dan logis untuk melakukan perbaikan terhadap suatu kondisi nyata; (2) memperdalam pemahaman terhadap tindakan yang dilakukan; dan (3) memperbaiki situasi dan kondisi sekolah / pembelajaran secara praktis”. Secara singkat, PTS ini bertujuan untuk mencari permasalahan nyata yang terjadi di sekolah-sekolah, sekaligus mencari jawaban ilmiah bagaimana masalah-masalah tersebut bisa dipecahkan melalui suatu tindakan perbaikan. Penelitian Tindakan Sekolah ini menggunakan pendekatan gabungan kuantitatif dan kualitatif. Penelitian ini menggunakan instrument daftar hadir dan instrumen kuisioner. Instrument pertama dipakai untuk pantauan harian dan instrument berikutnya dipakai diakhir siklus sebagai bagian dari evaluasi. Penerapan insentif ini diamati 2 Siklus. Hasilnya penerapan pemberian insentif bagi tata usaha mengalami peningkatan kehadiran dalam melaksanakan tugasnya sebesar sekitar 70%

Kritik Otoritas Pemaknaan Hadis Menuju Masyarakat Islam Berkemajuan

Sepeninggal Rasulullah Saw. perdebatan seputar keabsahan hadis sebagai sumber hukum Islam tampaknya tidak akan menemukan akhir. Bahkan, kecenderungan dalam hal ini mengarah kepada semakin tingginya intensitas perdebatan seputar keabsahan dan keotentikan hadis. Ini tidak hanya terjadi di kalangan ulama hadis yang muslim, tetapi juga di kalangan orientalis Barat non muslim yang menaruh perhatian kepada studi hadis

Bode, C., Helmy, M., & Bertamini, M. (2017). A cross-cultural comparison for preference for symmetry: comparing British and Egyptians non-experts..

The aesthetic appeal of symmetry has been noted and discussed by artists, historians and scientists. To what extent this appeal is universal is a difficult question to answer. From a theoretical perspective, cross-cultural comparisons are important, because similarities would support the universality of the response to symmetry. Some pioneering work has focussed on comparisons between Britain and Egypt (Soueif & Eysenck, 1971, 1972), including both experts and naive subjects. These studies confirmed some degree of universal agreement in preferences for simple abstract symmetry. We revisited this comparison after almost half a century. We compared preferences of naïve students in Egypt (n = 200) and Britain (n= 200) for 6 different classes of symmetry in novel, abstract stimuli. We used three different measurements of complexity: Gif ratio, Edge length and the average cell size (average blob size, ABS). The results support Soueif & Eysenck’s findings regarding preferences for reflectional and rotational symmetry, however they also throw new light on a greater preference for simplicity in Egyptian participants already noted by Soueif & Eysenck (1971)

Surfactant-induced migration of a spherical drop in Stokes flow

In Stokes flows, symmetry considerations dictate that a neutrally-buoyant spherical particle will not migrate laterally with respect to the local flow direction. We show that a loss of symmetry due to flow-induced surfactant redistribution leads to cross-stream drift of a spherical drop in Poiseuille flow. We derive analytical expressions for the migration velocity in the limit of small non-uniformities in the surfactant distribution, corresponding to weak-flow conditions or a high-viscosity drop. The analysis predicts that the direction of migration is always towards the flow centerline.Comment: Significant extension with additional text, figures, equations, et

Pengembangan Human Machine Interface (HMI) pada Simulator Sortir Bola sebagai Media Pembelajaran Otomasi Industri

Human Machine Interface (HMI) and Programmable Logic Controller (PLC) are widely used in the industry to monitor and control the production process. As part of industrial automation technology, expertise in designing HMI and programming PLC are an absolute necessity especially in the industrial 4.0 era which demands a professional and competent workforce. To meet these requirements, Program Studi Teknik Elektro Universitas Dian Nuswantoro has evaluated the curriculum, especially in the Elektronika Industri course. Based on stakeholder recommendation, learning outcomes are modified to support the graduate's profile that has expertise in industrial automation technology. Furthermore, a ball sorting simulator has been used as a medium for learning industrial automation. Unfortunately, the simulator only supports PLC learning. Therefore, it is necessary to develop the HMI system in the simulator. This paper explains the design and development of the HMI system based on Mitsubishi GOT2000 using the GT Designer3 application. The development of the HMI system starts from determining I/O and process parameters, making the layout, modifying the ladder diagram, and testing. Based on the test results, the HMI system can work well so that technically the ball sorting simulator has supported the learning of industrial automation technology both in PLC and HMI fields.Keywords : automation, learning, simulator, PLC, HMI AbstrakHuman Machine Interface (HMI) dan Programmable Logic Controller (PLC) digunakan luas di industri guna memonitor dan mengatur proses produksi. Sebagai bagian dari teknologi otomasi industri, penguasaan keahlian dan keterampilan mendesain HMI dan memprogram PLC menjadi kebutuhan mutlak terlebih di era industri 4.0 yang menuntut tenaga kerja profesional dan kompeten. Guna memenuhi tuntutan tersebut, Program Studi Teknik Elektro Universitas Dian Nuswantoro telah melakukan evaluasi terhadap kurikulum khususnya pada mata kuliah Elektronika Industri. Berdasarkan masukan dari stakeholder, Program Studi menambahkan capaian pembelajaran mata kuliah yang mendukung profil lulusan dengan penguasaan teknologi otomasi industri khususnya PLC dan HMI. Selain itu, sebuah simulator sortir bola telah rutin digunakan sebagai media pembelajaran otomasi industri. Namun, simulator tersebut terbatas untuk media pembelajaran PLC. Oleh karena itu, perlu dilakukan pengembangan sistem HMI pada simulator. Makalah ini membahas perancangan dan pengembangan sistem HMI berbasis panel Mitsubishi GOT2000 menggunakan aplikasi GT Designer3. Pengembangan sistem HMI dimulai dari penentuan I/O dan parameter proses sortir, pembuatan layout, modifikasi ladder diagram dan pengujian. Berdasarkan hasil pengujian yang telah dilakukan, sistem HMI dapat bekerja dengan baik sehingga secara teknis simulator sortir bola telah mendukung proses pembelajaran teknologi otomasi industri baik PLC maupun HMI.Kata Kunci : otomasi, pembelajaran, simulator, PLC, HM